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Since the discovery of the DNA structure researchers have been highly interested in the molecular basis of genome inheritance. This book covers a wide range of aspects and issues related to the field of DNA replication. The association between genome replication, repair and recombination is also addressed, as well as summaries of recent work of the replication cycles of prokaryotic and eukaryotic viruses. The reader will gain an overview of our current understanding of DNA replication and related cellular processes, and useful resources for further reading.
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The book collects the works presented during the XII meeting of the Italian Group of Evolutionary Biology, held in Florence in February 2004. Evolutionary theories are illustrated with balance from different points of view (from the perspective of historians, zoologists, paleontologists, anthropologists, molecular biologists) in the light of some recent experimental and theoretical discoveries. The debate and the diversity of investigations demonstrate the validity and relevance of the study of biological evolution.
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Genes and Common Diseases presents an up-to-date view of the role of genetics in modern medicine, reflecting the strengths and limitations of a genetic perspective. The current shift in emphasis from the study of rare single gene disorders to common diseases brings genetics into every aspect of modern medicine, from infectious diseases to therapeutics. However, it is unclear whether this increasingly genetic focus will prove useful in the face of major environmental influences in many common diseases. The book takes a hard and self-critical look at what can and cannot be achieved using a genetic approach and what is known about genetic and environmental mechanisms in a variety of common diseases. It seeks to clarify the goals of human genetic research by providing state-of-the art insights into known molecular mechanisms underlying common disease processes while at the same time providing a realistic overview of the expected genetic and physiological complexity.
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This volume is a collection of contributions of a Florentine post congress symposium on "Primate Cytogenetics and Comparative Genomics" held on occasion of the XX International Primatological Congress (Turin in 2004). Comparative Molecular Cytogenetics and Genomics are two rapidly expanding fields. Researchers from Italy, Germany, Spain, United States and Japan meet in Florence to discuss over a two day period recent advances and summarize the current state of the science.
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"Available Open Access under CC-BY-NC licence. The public and parliamentary debate about UK abortion law is often diverted away from key moral and political questions by disputes regarding basic questions of fact. And all too often, claims of scientific 'fact' are ideologically driven. With each chapter written by leading experts in the fields of medicine, law, reproductive health and social science, this book offers a concise and authoritative account of the evidence regarding the likely impact of decriminalisation. Examining specific yet diverse regional and local contexts across Europe, this book uses original research to evaluate differences in scope, approach, orientation, and objectives. It examines the embedding of LLL policies into the regional economy, the labour market, education and training systems and the individual life projects of young people, with a focus on those in situations of near social exclusion."
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Over the last twenty years, genome-wide association studies (GWAS) have revealed a great deal about the genetic basis of a wide range of complex diseases and they will undoubtedly continue to have a broad impact as we move to an era of personalised medicine. This authoritative text, written by leaders and innovators from both academia and industry, covers the basic science as well as the clinical, biotechnological and pharmaceutical potential of these methods. With special emphasis given to highlighting pharmacogenomics and population genomics studies using next-generation technology approaches, this is the first book devoted to combining association studies with single nucleotide polymorphisms, copy number variants, haplotypes and expressed quantitative trait loci. A reliable guide for newcomers to the field as well as for experienced scientists, this is a unique resource for anyone interested in how the revolutionary power of genomics can be applied to solve problems in complex disease.
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